Abstract
Human sperm carry a nicotinic cholinergic receptor. Nevertheless, the effects of nicotine on sperm fertilizing functions have been controversial. We have previously reported that in vitro treatment of human sperm with nicotine and its metabolite significantly altered three sperm functions: hyperactivation, acrosomal status, and binding to the zona pellucida. In this new study, we have examined whether sperm from chronic tobacco smokers are defective in binding to the human zona pellucida.
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