Abstract
Background and Aims: Various macrophages are implicated the progression of atherosclerotic towards rupture: dying foamy macrophages (FMs), at the onset of the lipid core, and inflammatory macrophages (M1) in higher proportion than regulatory macrophages (M2). M1, M2 and FM models present distinct optical properties in TPEF imaging, with a higher NADH autofluorescence in M1 and FMs than in M2, and a higher FAD autofluorescence in FMs than in M1 and more unexpectedly than in M2. We hypothesized that, as in murine macrophages, human M1 may use glycolysis and M2 the OXPHOS pathway, while human FMs may use both but mostly the OXPHOS pathway.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
