The small intestine and gastric secretion in the rat. The effects of intestinal bypass, resection, and supplemental hydration on interdigestive gastric secretion.

Abstract

Resection of the distal 40% of small intestine increased the total acid output in female Holtzman rats when compared to that of controls. This effect was not seen in animals with the same intestinal segment bypassed. The administration of saline either subcutaneously or intraluminally in animals with bypassed intestinal segments caused similar elevations of total acid output above those of controls and suggest that dehydration contributed to the previous lack of response. We have also shown that distention of the intestine, per se, did not influence the gastric secretion in this preparation. Further investigation of hydration differences is necessary in order to separate the secretory responses: that due to resection or bypass from that due to the fluid state alone.