Abstract
From mining EST databases with an algorithm designed to identify helical cytokines, Blumberg et al. have turned up interleukin 20 (IL-20), a cytokine that appears to regulate the epidermis. When IL-20 was overexpressed in transgenic mice, skin abnormalities reflecting hyperproliferation were observed. Biochemical analysis of known class II cytokine receptors revealed that IL-20 binds to a specific heterodimeric receptor that is expressed in human skin, and it is also overexpressed in skin of psoriasis patients. The report suggests that IL-20 may exert its effects through a pathway involving signal transducers and activators of transduction elements (STATS), as STAT3 translocated to the nucleus when cells overexpressing the IL-20 receptor were treated with the cytokine.H. Blumberg, D. Conkin, W. Xu, A. Grossmann, T. Brender, S. Carollo, M. Eagen, D. Foster, B. A. Haldeman, A. Hammond, H. Haugen, L. Jelinek, J. D. Kelly, K. Madden, M. F. Maurer, J. Parrish-Novak, D. Prunkard, S. Sexson, C. Sprecher, K. Waggie, J. West, T. E. Whitmore, L. Yao, M. K. Kuechle, B. A. Dale, Y. A. Chandrasekher, Interleukin 20: Discovery, receptor identification, and role in epidermis function. Cell 104, 9-19 (2001). [Online Journal]
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
