Abstract
目的 探讨甲状腺癌中p16和Rb蛋白的表达、相互关系及其意义.方法应用免疫组织化学SP法检测80例甲状腺癌患者组织中p16和Rb蛋白的表达情况.结果p1 6和Rb总异常表达率,甲状腺腺瘤为12.5%;80例甲状腺癌中,低度恶性组为66.7%,高度恶性组为87.0%.p1 6阳性率,低度恶性组为64.9%(37/57);高度恶性组为34.8%(8/23).Rb阳性率,低度恶性组为68.4%(39/57);高度恶性组39.1%(9/23);癌组织分化越差,p1 6及Rb阳性率越低.P16和Rb蛋白均阳性的肿瘤术后复发转移率低.结论甲状腺癌的发生发展与p16和Rb蛋白缺失有关;瘤组织分化程度越差,p16和Rb蛋白丢失越多;p16和Rb蛋白均阳性的肿瘤术后复发率转移率低:p16和Rb蛋白的表达具有负相关关系,二者共同作用才能阻止瘤细胞的增殖。
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