Abstract
BackgroundTo investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients.MethodsA total of 244 TN patients and 280 age and sex matched healthy volunteer were recruited. 5-HTTLPR and rs 25531 genotyping were performed. All patients received the carbamazepine treatment and the treatment response was evaluated at 6 months.ResultsThe genotype distribution of 5-HTTLPR between TN patients and controls were significantly different. The TN Patients had a higher prevalence of short-short genotype than controls. The short-short genotype carriers are also significantly associated with higher pain severity and poorer carbamazepine treatment response compared to the long-long genotype carriers. In contrast, the rs 25531 polymorphism was not associated with the susceptibility to TN, neither with the pain severity and the treat response to carbamazepine.ConclusionThe 5-HTTLPR polymorphism is associated with the susceptibility to TN and pain severity of TN.
Highlights
To investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients
5-HTTLPR gene polymorphism influences the analgesic response to the short acting opioid Remifentanil in human [17]
The 5-HTTLPR genotype frequencies in the control group were in Hardy– Weinberg equilibrium (P = 0.486), those of Trigeminal neuralgia (TN) group were different from those expected under Hardy– Weinberg equilibrium (P = 0.005)
Summary
To investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients. The serotonin transporter gene (5-HTT)-linked polymorphic region (5-HTTLPR) plays an important role in regulating 5-HTT expression and thereby controlling the concentration of serotonin (5-HT) in brain synapses [15,16]. Recent studies reveal close associations between the genetic variation in the 5-HTTLPR and rs25531 with several pain conditions. 5-HTTLPR gene polymorphism influences the analgesic response to the short acting opioid Remifentanil in human [17]. Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) confers the analgesic response to the short acting opioid Remifentanil in humans [17]
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