Abstract
The use of dietary α-methyl dopa, an inhibitor of Drosophila melanogaster dopa decarboxylase, to screen for mutants defective in cuticle development was investigated. The results show that dietary α-methyl dopa is toxic to larvae and that death always occurs at the larval molts. This and other evidence suggests that α-methyl dopa is a specific inhibitor of some aspect of cuticle development. From a screen of 2748 EMS-treated lethal-free second chromosomes, 7 dominant α-methyl dopa hypersensitive mutants were obtained. All these mutants are recessive lethal alleles on standard food and map to one locus, 53.1±, designated as l(2)amd. Assays of dopa decarboxylase activities do not reveal any differences between mutant heterozygotes (l(2)amd/+) and wild type (+/+).
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