Abstract
In principle, an AP site could be released by two hydrolytic events, one nicking the phosphodiester bond 3′, the other the phosphodiester bond 5′ to the AP site. Since in each phosphodiester bond, there are two linkages, C3′-O-P and C5′-O-P, that can be hydrolyzed, four different hydrolases might participate in the excision of AP sites. In fact, we know a single class of AP endonucleases; these enzymes hydrolyze the C3′-O-P bond 5′ to AP sites and the resulting nicks are limited by 3′-OH and 5′-phosphate ends.
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