Abstract
Current study experiments were conducted on male Rattus rattus norvigicus, at age of two months, with theweight of (200-250gm) divided into 8 groups for each group of 8 rats. The lethal average dose of (LD50) forcadmium chloride and the choice of bodyweight (5mg/kg) to inject rats Intraperitonially were determined,then orally doses of vitamin D3 after a week of CdCl2 injection at a concentration of 1000IU/kg bodyweightat three doses per week as well as for the rest of the concentrations, 2000IU/kg bodyweight, and 4000IU/kgbodyweight. After four weeks of injection and administration, blood was drawn from the rats in each group,then the rats were slaughtered and the liver was taken for tests. The current study aimed to use differentconcentrations of vitamin D3 as a treatment, the antioxidant in the liver of rats injected with heavy metalCdCl2. Due to the study, some biochemical, physiological, and tissue changes in them through the study ofliver function for rats experimenting with transactions, in addition to studying the level of oxidative stressand antioxidants in the liver. The results of the current study have shown that the role of vitamin D3 as anantioxidant and as a treatment in reducing the toxic effect of CdCl2 to a very large. The best concentration ofvitamin D3 used in the case study was 2000 IU/kg bodyweight, which was taken for rats and three doses perweek for four weeks, and after being injected with CdCl2, there was a significant decrease at the probabilitylevel P?0.05 for the concentration of the ALT when compared to the control group. On the other hand, thereis a significant rise in glutathione (GSH) and catalase (CAT) levels in rat liver, at the same concentrationof vitamin D3, when compared with the control group, while there was a clear improvement in AST andmalondialdehyde (MDA) in the liver, the results were very similar to those of the control group. Perhapsvitamin D3 dosage of cadmium-injected rats may protect improving the toxic effect of CdCl2 in the liver.
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