Abstract
RNA viruses are metastable macromolecular assemblies that sense their environment through dynamic breathing motions. While surfaces of viral particles have been well characterized by cryo-EM, dynamic genome-capsid cores are poorly understood. To address this gap in understanding, we have applied hydrogen deuterium exchange mass spectrometry (HDXMS) together with cryo-EM to Turnip Crinkle Virus (TCV) as a model system to study RNA genome-capsid interactions and their importance in environmental sensing and programmed viral disassembly in favorable host environments.
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