Abstract
Summary and ConclusionsThese hematologic and histologic data indicate that:1) Severe anemia, leucopenia, and thrombocytopenia develop in mice after a single dose of 600 r whole-body X radiation.2) Ectopic erythrocytopoiesis, in the lead-protected spleens of mice given 600 r whole-body X radiation (exclusive of spleens) compensates with such rapidity and so extensively for the destruction and interruption of this activity in the marrow spaces that no anemia of significance becomes apparent. Ectopic granulocytopoiesis and megakaryocytopoiesis in the lead-protected spleens compensates significantly but at a slower pace and less completely for the bone marrow destruction.3) A marked and sustained decrease in the amount of lymphatic tissue is produced in the lead-protected spleens of animals given 600 r whole-body X radiation. This decrease in lymphatic tissue may perhaps be a result of (a) unsuccessful competition of the lymphatic tissue with the ectopic hematopoiesis for nutritional requirements, (b) actual ...
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