Abstract
BackgroundIt’s necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS).MethodsNewly diagnosed PCOS patients treated in our hospital were selected, and healthy women who took physical examination during the same period as healthy controls. We detected and compared the related serum indicators between two groups, Pearson correlation were conducted to identify the factors associated with β-trophin and ES, and the influencing factors of β-trophin and ES were analyzed by logistic regression.ResultsA total of 62 PCOS patients and 65 healthy controls were included. The BMI, WHI, LH, FSH, TT, FAI, FBG, FINS, HOMA-IR, TC, TG, LDL, ES in PCOS patients were significantly higher than that of healthy controls, while the SHBG and HDL in PCOS patients were significantly lower than that of healthy controls (all p < 0.05). β-trophin was closely associated with BMI (r = 0.427), WHR (r = 0.504), FBG (r = 0.385), TG (r = 0.405) and LDL (r = 0.302, all p < 0.05), and ES was closely associated with BMI (r = 0.358), WHR (r = 0.421), FBG (r = 0.343), TC (r = 0.319), TG (r = 0.404, all p < 0.05). TG, BMI, WHR and FBG were the main factors affecting the serum β-trophin levels (all p < 0.05). FBG, TC and BMI were the main factors affecting the serum ES levels (all p < 0.05). The TG, β-trophin, ES level in PCOS patients with insulin resistance (IR) were significantly higher than that of those without IR (all p < 0.05).ConclusionIncreased β-trophin is closely associated with increased ES in patients with PCOS, which may be the useful indicators for the management of PCOS.
Highlights
It’s necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS)
The pathogenesis of PCOS is still not completely clear, insulin resistance (IR) and its compensatory hyperinsulinemia are one of its pathogenesis, and it’s been reported that 70% PCOS patients have the symptoms of IR [8, 9]. β-trophin, which is secreted by the liver and adipose tissue, has been found that plays a dual role in regulating lipid metabolism and improving glucose tolerance [10]
The results showed that TG, body mass index (BMI), WHR and Fasting blood glucose (FBG) were the main factors affecting the serum β-trophin levels
Summary
It’s necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS). Previous studies [11, 12] have shown that serum β-trophin levels are higher in patients with IR-related metabolic diseases (diabetes, obesity, etc.), yet the role of β-trophin in PCOS needs further investigation. Studies [13, 14] have shown that ovarian angiogenesis and interstitial blood flow increase in patients with PCOS, so angiogenesis disorders may be one of the main reasons for the occurrence and development of PCOS. Previous studies [16, 17] have shown that the levels of ES in patients with PCOS are abnormally elevated, but the specific mechanism needs further research. We aimed to analyze the role of β-trophin and ES in patients with PCOS, to provide the insights and evidences into the treatment of PCOS
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