Abstract
Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago. RNA editing alters RNA sequence without altering the sequence or integrity of genomic DNA. The most common RNA editing events are A-to-I changes mediated by adenosine deaminase acting on RNA (ADAR), and C-to-U editing mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1). Both A-to-I and C-to-U editing were first identified in the context of embryonic development and physiological homeostasis. The role of RNA editing in human disease has only recently started to be understood. In this review, the impact of RNA editing on the development of cancer and metabolic disorders will be examined. Distinctive functions of each RNA editase that regulate either A-to-I or C-to-U editing will be highlighted in addition to pointing out important regulatory mechanisms governing these processes. The potential of developing novel therapeutic approaches through intervention of RNA editing will be explored. As the role of RNA editing in human disease is elucidated, the clinical utility of RNA editing targeted therapies will be needed. This review aims to serve as a bridge of information between past findings and future directions of RNA editing in the context of cancer and metabolic disease.
Highlights
The Role of RNA Editing in Cancer Development and Metabolic DisordersReviewed by: Marco Ghezzi, Padua University, Italy Luis Del Valle, LSU Health Sciences Center New Orleans, United States
Genetic complexity, or plasticity, is the foundation to develop complicated biological functions in living organisms
Data from one patient with a predisposition to type 2 diabetes showed that C-to-U editing is the second most frequent RNA editing event, indicating that RNA editing mediated by APOBEC1 or other C-to-U editases is an important factor in metabolic homeostasis [78]
Summary
Reviewed by: Marco Ghezzi, Padua University, Italy Luis Del Valle, LSU Health Sciences Center New Orleans, United States. The most common RNA editing events are A-to-I changes mediated by adenosine deaminase acting on RNA (ADAR), and C-to-U editing mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1). Both A-to-I and C-to-U editing were first identified in the context of embryonic development and physiological homeostasis. The impact of RNA editing on the development of cancer and metabolic disorders will be examined. This review aims to serve as a bridge of information between past findings and future directions of RNA editing in the context of cancer and metabolic disease
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.