Abstract
Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function.
Highlights
Resveratrol (3,5,40 -trihydroxystilbene) is a polyphenol that belongs to dietary stilbenes, a class of natural compounds that display significant biological activities of medicinal interest
These authors found that the association of the two compounds in the medium of cumulus-oocyte complexes undergoing in vitro maturation (IVM) supported a synergistic increase in oocyte nuclear maturation and total cell numbers of parthenogenetic activated blastocysts, and improved the development of somatic cell nuclear transfer embryos [54]
Phosphorylation, allowing the reduction of reactive oxygen species (ROS) production, while enhancing the sperm antioxidative defense system such as GSH level and activities of glutathione peroxidase (GPx), Superoxide dismutase (SOD), and catalase (Figure 3). While it is well-established that resveratrol is capable of activating AMPK, the exact mechanism by which this occurs remains to be clarified [133]. This is because the activation of AMPK can take place through a variety of complex and apparently contradictory mechanisms, which include an increase in the AMP/ATP ratio [130]; inhibition of mitochondrial ATP synthase [134,135]; ROS [136,137]; as well as upstream serine/threonine kinases, such as LKB1 (Peutz–Jeghers protein) [138,139] and calcium/calmodulin-dependent protein kinase kinase b (CaMKKb) [140,141]
Summary
Resveratrol (3,5,40 -trihydroxystilbene) is a polyphenol that belongs to dietary stilbenes, a class of natural compounds that display significant biological activities of medicinal interest. This phenolic compound was initially characterized as a phytoalexin for its fungicidal role [6], and only later was it appreciated as a nutrient supplement, for several beneficial effects in the prevention and improvement of various diseases highlighted over the years [7]. From French people having incidence of coronary pathologies generally a long life expectancy likely due to moderate consumption of red wine despite a diet characterized by high saturated fat phenolic compound characterized as a phytoalexin for itshealth fungicidal intake [8]. The antioxidative effects of resveratrol are related to the reproduction, with a particular focus on animals of veterinary interest It will clarify the high redox propertyonofboth phenolic hydroxyl groups, which act free radical scavengers.ofResveratrol effect of resveratrol female and male reproduction andasdiscuss the mechanisms action. Excellent and exhaustive reviews on the role of resveratrol on pregnancy [11], on the ovarian
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
