Abstract
Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD). Global prevalence of NAFLD has been estimated to be around 25%, with gradual elevation of this ratio along with the increased content of adipose tissue in a body. The initial stages of NAFLD may be reversible, but the exposition to pathological factors should be limited. As dietary factors greatly influence various disease development, scientists try to find dietary components, helping to alleviate the steatosis. These components include n-3 polyunsaturated (PUFA) fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA). This review focused on the role of resolvins, protectins and merensins in NAFLD.
Highlights
Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD) [1]
This review explains mechanisms in which active eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) derivatives affect liver metabolism and NAFLD phenotype. It focused on the impact of resolvins, protectins, and marensins in liver metabolism and NAFLD pathophysiology, all of which were not discussed in existing reviews
The results indicated that n-3 PUFA supplementation may improve metabolic and cardiovascular risk factors and surrogate markers for NAFLD progression
Summary
Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD) [1]. As dietary factors greatly influence various disease phenotypes, scientists try to find dietary components helping to reduce the steatosis. This review explains mechanisms in which active EPA and DHA derivatives affect liver metabolism and NAFLD phenotype. It focused on the impact of resolvins, protectins, and marensins in liver metabolism and NAFLD pathophysiology, all of which were not discussed in existing reviews.
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