Abstract

Preterm premature rupture of membranes (PPROM), defined as the spontaneous rupture of the membranes before 37 weeks of gestation and prior to the onset of labor, is the leading identifiable cause of preterm delivery, occurring approximately in one third of all preterm births [1]. Although a single factor can seldom be assigned to PPROM, it is most strongly associated with the presence of intrauterine inflammation and/or infection [2]. In nearly half of PPROM cases, or cases of preterm labor with intact membranes, fetal inflammatory response syndrome is present—with increased production of lung surfactant and alterations to lung structure [3].

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