Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and progressive NAFLD can develop into non-alcoholic steatohepatitis (NASH), liver cirrhosis, or hepatocellular carcinoma (HCC). NAFLD is a kind of metabolic disordered disease, which is commonly associated with lipid metabolism, insulin resistance, oxidative stress, inflammation, and fibrogenesis, as well as autophagy. Growing studies have shown Notch signaling pathway plays a pivotal role in the regulation of NAFLD progression. Here, we review the profile of the Notch signaling pathway, new evidence of Notch signaling involvement in NAFLD, and describe the potential of Notch as a biomarker and therapeutic target for NAFLD treatment.
Highlights
Non-alcoholic fatty liver disease (NAFLD), affecting over a quarter of the global population, has emerged as the highest prevalent type of chronic liver disease (Younossi et al, 2016)
NAFLD is a manifestation of metabolic syndrome in the liver
The previous studies have revealed the significance of the Notch signaling pathway in metabolism
Summary
Non-alcoholic fatty liver disease (NAFLD), affecting over a quarter of the global population, has emerged as the highest prevalent type of chronic liver disease (Younossi et al, 2016). Reduce hepatic steatosis and improve glucose and insulin tolerance Initiate oxidative stress in hepatocyte Reduce NASH related liver fibrosis Ameliorate hepatic lipogenesis dyslipidemia and insulin resistance Improve glucose metabolism and ameliorate liver fibrosis Protect from obesity-induced insulin resistance Hepatoprotective and antitumorigenic effect in HCC cells Reduce biochemical markers of hepatocellular injury and steatosis
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