Abstract
Background and Aims: Obesity is one of the major health problems worldwide. Morbid obesity (body mass index >40 kg/m2 or over 35 with a comorbidity) is associated, apart from other diseases, with an increased risk of non-alcoholic fatty liver disease (NAFLD). Moreover, dyslipidemia is an important comorbidity that is frequently found in NAFLD patients. The aim of this study was to analyze whether serum lipids in morbidly obese patients are associated with the spectrum of NAFLD.Methods: Total serum cholesterol, LDL cholesterol, HDL cholesterol, non-HDL cholesterol, VLDL, and triglycerides were analyzed in 90 morbidly obese patients. The association of lipid profile parameters with histopathological, elastographic, and sonographic indices of NAFLD, non-alcoholic steatohepatitis (NASH), and liver fibrosis were explored.Results: The mean levels of serum total cholesterol, LDL-C, and non-HDL cholesterol in patients with positive histology for liver steatosis and NASH were significantly higher than those in patients with negative histology. None of the indices showed a strong association with NAFLD, NASH, or liver fibrosis after adjustment for potential confounders.Conclusion: A slight predictive value of lipid profile is not sufficiently enough to use solely as a non-invasive test in predicting NASH or liver fibrosis.
Highlights
Non-alcoholic fatty liver disease (NAFLD)—the most common cause of liver disease—is described as the presence of hepatic fat accumulation exceeding 5% of liver weight in the absence of excessive alcohol use
None of the indices showed a strong association with NAFLD, non-alcoholic steatohepatitis (NASH), or liver fibrosis after adjustment for potential confounders
About 3–30% of NAFLD patients have a relatively normal body mass index (BMI), NAFLD is strongly associated with obesity and hyperlipidemia, and it seems to be the hepatic manifestation of metabolic syndrome [4, 9,10,11,12]
Summary
Non-alcoholic fatty liver disease (NAFLD)—the most common cause of liver disease—is described as the presence of hepatic fat accumulation exceeding 5% of liver weight in the absence of excessive alcohol use. About 3–30% of NAFLD patients have a relatively normal body mass index (BMI), NAFLD is strongly associated with obesity and hyperlipidemia, and it seems to be the hepatic manifestation of metabolic syndrome [4, 9,10,11,12]. Several methods, both invasive and non-invasive, have been suggested to evaluate liver fat content, NASH and fibrosis. Morbid obesity (body mass index >40 kg/m2 or over 35 with a comorbidity) is associated, apart from other diseases, with an increased risk of non-alcoholic fatty liver disease (NAFLD).
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