Abstract
The long-term change of the light mode for three months – light desynchronosis, disturbs the rhythm of the signals received from the external pacemaker. As a result of the study, it was found that a long-term change in the light mode and a violation of the rhythmicity of signals received from an external pacemaker contributes to the activation of ROS formation as triggers for bioenergetic processes in the cell. At the same time, changing the light mode disrupts the balance of oxygen in the cell and this is a provoking factor for the stress of the antioxidant cell system. The resulting tissue hypoxia in chronic light desynchronosis disrupts the bioenergetic potential of the cell, contributing to the development of pathophysiological processes and the death of neurons. Therefore, a violation of the balance of the pro-oxidant and anti-oxidant systems leads to destructive processes in the brain. A significant change in the concentration of the neurotrohic markers indicates destructive processes in the brain tissues. Summarizing the above, we conclude that light desynchronosis is directly involved in the ROS-dependent stress-induced aging of brain cells and in that way, to the progression of processes that lead to aging of the body.
Highlights
According to the classical definition, aging is a multi-cause destructive process caused by a complex of regulatory and stochastic factors and determined by the genetically determined biological organization of the living system [1].Experimental studies on various model organisms have confirmed the possibility of increasing stress resistance and prolonging active life as a result of environmental influences [2, 3]
After 1 month of stay of animals under constant lighting, a significant increase in diene conjugates was detected in the brain tissue homogenate by 7.3% compared to the value of this indicator in the brain homogenate of animals from the group with normal light
The activity of glutathione transferase (GT) in the homogenate of both groups with a changed light mode significantly decreases by 16.1% – in the group with constant light, and by 18.8 % – in the group with constant darkness compared to the values of indicators from the group with normal light
Summary
According to the classical definition, aging is a multi-cause destructive process caused by a complex of regulatory and stochastic factors and determined by the genetically determined biological organization of the living system [1].Experimental studies on various model organisms have confirmed the possibility of increasing stress resistance and prolonging active life as a result of environmental influences [2, 3]. Light activates the expression of clock genes through the generation of reactive oxygen species, mainly Н2О2 This leads to the formation of redox oscillator molecules: oxidized glutathione, glutathione peroxidase, NADP+. It is obvious that there is a link between the oscillators of the membrane, cytosol and nucleus Such effects can be mediated, for example, by cAMP and Ca2+ ions as the main buffer of acidosis. They are involved in circadian changes in membrane potential, metabolism, and energy exchange, in posttranslational modification of histones, and in the expression of per and cry genes by transcription factor CREB after its phosphorylation by calcium/calmodulin-dependent kinase (CaMKII) and cAMP [8,9,10,11,12]
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