Abstract
Transections of interpeduncular nucleus efferents to the paramedian midbrain tegmentum were produced by means of a horizontal knife cut placed along the dorsal border of the interpeduncular nucleus. Animals with knife cuts displayed an improvement in the acquisition of a two-way shuttle box avoidance task and were impaired in their ability to suppress licking at an electrified drinking spout. These results suggest that caudally directed interpeduncular efferents may modulate the activity of limbic-midbrain systems involved in avoidance behavior.
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