Abstract
The field of neuroimmunology is providing growing evidence of active crosstalk between the immune system and the nervous system in health and during diverse pathological conditions. Experimental and clinical research now suggests that signaling from periphery to brain is important for maintaining homeostasis, but also has the potential to impact brain disease initiation or progression. Knowledge and understanding of the cellular and molecular mechanisms governing immune-to-brain bidirectional communication is providing key insights to better model neuroimmune communication, understand the clinical implications, and design better therapies for CNS disorders with an inflammatory component.
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