Abstract
BackgroundNorovirus, the leading cause of gastroenteritis, causes higher morbidity and mortality in nursing homes (NHs) than in the community. Hence, implementing infection control measures is crucial. However, the evidence on the effectiveness of these measures in NH settings is lacking. Using an innovative data-driven modeling approach, we assess various interventions to control norovirus spread in NHs.MethodsWe collected data on resident and staff characteristics and inter-human contacts in a French NH. Based on this data, we developed a stochastic compartmental model of norovirus transmission among the residents and staff of a 100-bed NH. Using this model, we investigated how the size of a 100-day norovirus outbreak changed following three interventions: increasing hand hygiene (HH) among the staff or residents and isolating symptomatic residents.ResultsAssuming a baseline staff HH compliance rate of 15 %, the model predicted on average 19 gastroenteritis cases over 100 days among the residents, which is consistent with published incidence data in NHs. Isolating symptomatic residents was highly effective, leading to an 88 % reduction in the predicted number of cases. The number of expected cases could also be reduced significantly by increasing HH compliance among the staff; for instance, by 75 % when assuming a 60 % HH compliance rate. While there was a linear reduction in the predicted number of cases when HH practices among residents increased, the achieved impact was less important.ConclusionsThis study shows that simple interventions can help control the spread of norovirus in NHs. Modeling, which has seldom been used in these settings, may be a useful tool for decision makers to design optimal and cost-effective control strategies.
Highlights
Norovirus, the leading cause of gastroenteritis, causes higher morbidity and mortality in nursing homes (NHs) than in the community
Norovirus gastroenteritis is one of the most frequent causes of outbreaks in NH settings [2], leading to increased death and hospitalization rates; for instance, a US study showed that long-term care residents were four times more likely to die from gastroenteritis than people living in the community [3]
As person-to-person transmission plays an important part in norovirus spread and compliance with international hygiene recommendations is low in NH staff [6], it is expected that increasing hand hygiene practices could help limit norovirus outbreaks
Summary
The leading cause of gastroenteritis, causes higher morbidity and mortality in nursing homes (NHs) than in the community. Using an innovative data-driven modeling approach, we assess various interventions to control norovirus spread in NHs. Combined with community life and limited resources, the increased vulnerability of older adults leads to a high prevalence of infections in nursing homes (NHs), with major consequences in terms of morbidity, mortality and costs [1]. As person-to-person transmission plays an important part in norovirus spread and compliance with international hygiene recommendations is low in NH staff [6], it is expected that increasing hand hygiene practices could help limit norovirus outbreaks. The evidence on hand hygiene effectiveness in NH settings is limited [7] and the way hand hygiene may impact norovirus transmission dynamics is poorly understood
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