Abstract
Fibrin related markers include several proteins and fragments developed in the conversion of fibrinogen to cross-linked fibrin and following degradation.FDP played as a more important role than conventional global coagulation test before application of D-dimer in clinical settings,moreover,combination of FDP and D-dimer improve the diagnostic of DIC greatly,and D-dimer has become an effective tool excluding venous thromboembolism besides the imaging.Whether basic or clinical research on soluble fibrin monomers and complexes were focused in an early stage,however,limited by diversity of analytes and non-standardization,no full application was come into being.It is worthwhile to note that fibrin related markers release into plasma sequentially from initialization of fibrinogen activation to fibrinolysis. Thus,the combination of these index is useful to understand patient′s condition (such as DIC),prognosis of VTE recurrence,and prophylaxes of post-operation thrombosis.(Chin J Lab Med, 2014, 37:233-235) Key words: Disseminated intravascular coagulation; Fibrin; Biological markers
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