Abstract
The formation of complexes of curcumin and Fe(II) was studied in aqueous media at pH 5.7 ± 0.1 by polarography, amperometry and spectrophotometry. The polarogram indicated formation of complexes between curcumin and Fe(II). Curcumin produces a well-defined direct current polarogram and differential pulse polarogram in 0.1 M ammonium tartrate (supporting electrolyte) at pH 5.7 ± 0.1. The stoichiometry of the Fe(II)-curcumin complex is 1 : 1. Anticancer studies on the drug and its metal complex have been performed against sarcoma cells (in-vitro), revealing the complex to be more potent in anticancer activity compared to the parent drug.
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