Abstract
Publisher Summary The Ets (E26-transformation specific or E-twenty-six-specific) family of eukaryotic transcription factors is a large (and rapidly growing) set of winged helix-loop-helix DNA-binding proteins all of which recognize a purine-rich sequence motif centered around the core sequence, GGA/T. Invertebrate Ets proteins are both positive and negative regulators of a wide variety of important developmental events, including vulval cell-fate determination in Caenorhabditis elegans and steroid hormone-induced metamorphosis photoreceptor development in Drosophila . The fine mapping of Ets phosphorylation sites and an understanding of the role of individual sites in regulating specific functions, such as DNA binding and protein–protein interactions, will also be essential for understanding the regulation of Ets proteins, as will the elucidation of the signaling pathways that lead to the phosphorylation of Ets proteins following immune cell activation. It is important to identify additional partners that interact with Ets proteins to regulate their transcriptional activities. According to this chapter, recent rapid progress in this field seems safe to predict that the next 5 years will represent a second revolution in the understanding of the role of Ets transcription factors in immune cell function.
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