Abstract
Background Nucleolar organizer regions are parts of chromosomes that code ribosomal RNA and correlate to cellular proliferation. They have been identified by means of an argyrophilic technique that reveals NORs as black dots in the nuclei. The method has been recently applied in some malignancies, as lymphoma or melanoma. Only few investigations on hormonal-dependent tumours have been published. Our aim was to investigate on the total number of AgNORs and cell type of endometrial tumors. Material and Methods We studied 21 cases of formalin fixed paraffin embedded endometrial tumors including hyperplasia. The number of AgNORs was counted in both epithelial and stromal components. A total of 13 cases were benign and 8 malignant lesions. Results The total number of AgNORs was found to correlate with mitotic counts both in benign lesions and malignancies. The mean number of AgNORs increased from 2.79 in simple endometrial hyperplasia to 10.0 in adenocarcinoma. Conclusions Our data indicate that the AgNORs visualization can assist to differentiate between different malignancy grades of endometrial proliferations, especially between complex endometrial hyperplasia and atypical hyperplasia as well as endometrial adenocarcinomas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
