Abstract
SummaryAtopic dermatitis (AD) is a biphasic inflammatory skin disease characterized by an initial phase predominated by Th2 cytokines which switches into a second and more chronic Th1 dominated eczematous phase. Two different, the high affinity receptor for IgE (FcεRI) bearing dendritic cell subtypes have been identified in the skin of AD patients: FcεRIhigh Langerhans cells (LC) and FcεRIhigh inflammatory dendritic epidermal cells (IDEC). These two dendritic cell subtypes are supposed to contribute distinctly to the biphasic nature and the outcome of T‐cell responses in AD. In the light of recent developments a picture emerges that different IgE‐receptor bearing DC subtypes in the blood and the skin of AD patients play a pivotal role in the complex pathophysiological network of AD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
