Abstract
The synthesis of protein by human embryonic fibroblasts in vitro was stimulated by irradiation with ultrasound at a frequency of 3 MHz, a spatial and temporal peak intensity of 0.5 W.cm −2, pulsed at a mark: space ratio of 2:8 ms for 5 min at ambient pressure. This stimulation was suppressed by the application of a positive pressure of two atmospheres during irradiation, although increasing the pressure in the absence of ultrasound had no significant effect on the rate of protein synthesis in control cells. Dilatation of the rough endoplasmic reticulum and plasma membrane changes, found in the majority of cells after treatment with ultrasound at ambient pressure, were also suppressed in cells irradiated at elevated pressure. Since it is unlikely that increasing the pressure could modify any ultrasonic effect other than cavitation, these results suggest that cavitation is involved in the mechanism of stimulation.
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