Abstract
RATIONALE: Bruton's tyrosine kinase (Btk) has recently been demonstrated to play an important role in signaling pathways of multiple toll-like receptors (TLR). In this study we examined the effect of Btk deficiency in X-linked agammaglobulinemia (XLA) patients on TLR signaling, and the role that Btk might play in normal controls and common variable immunodeficiency (CVID) patients with known TLR defects.
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