Abstract
Murine hepatitis virus (MHV) strain A59 infects the central nervous system (CNS) and liver of mice, causing encephalitis and hepatitis. Virus is cleared from both organs by 16 days post-infection (dpi) (Lavi et al, 1986; data not shown). Infection of the CNS by this virus is associated with demyelination. Interestingly, demyelination peaks at around 30 dpi, after infectious virus is cleared and only viral RNA and small amounts of protein remain (Lavi et al, 1984a, 1984b; Sutherland et al, 1997; data not shown).
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