Abstract
The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review.
Highlights
Breast cancer is the most frequently found cancer in the female population and one of the most prevalent causes of cancer-related deaths [1]
Both bone marrow adipocyte (BMA) and breast cancer cells secrete adipokines, and this review is focused on how BMAs and adipokines are involved in the process of breast cancer bone metastasis and how they can work as potential suppressive targets of bone metastasis
The role of adipokines and BMAs in breast cancer bone metastasis was explored in this review
Summary
Breast cancer is the most frequently found cancer in the female population and one of the most prevalent causes of cancer-related deaths [1]. The morbidity and mortality of breast cancer are mostly due to a distant metastasis, which most often occurs in the lung, liver, brain and bone [2,3]. Among these frequent sites of breast cancer metastasis, bone metastasis occurs in about two thirds of advanced breast cancer patients and leaves them with an expected survival of two to three years [4,5]. Breast cancer cells and bone are major factors involved throughout the process of bone metastasis in breast cancer, and bone marrow adipocyte (BMA) is one of the bone factors in the bone microenvironment. Both BMAs and breast cancer cells secrete adipokines, and this review is focused on how BMAs and adipokines are involved in the process of breast cancer bone metastasis and how they can work as potential suppressive targets of bone metastasis
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