Abstract
Toxins impairing the functions of cytoskeletal actin filaments – cytochalasin B (which inhibits actin polymerization and degrades microfilaments) and phalloidin (which prevents depolymerization of microfilaments, stabilizing F-actin) – weakened depression of the acetylcholine-induced influx current in defensive behavior command neurons in the common snail in conditions of rhythmic local applications of acetylcholine to the cell body (a cellular analog of habituation). These results, along with mathematical modeling, provide grounds for suggesting that depression of the cholinosensitivity of the extrasynaptic zones of command neuron membranes in the cellular analog of habituations is associated with the involvement of actin microfilaments in a reduction in the number of membrane cholinoreceptors.
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