Abstract
BackgroundAlthough accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types.MethodsOnline databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Pooled standardized incidence rates (SIRs) with 95% confidence intervals (CIs) were utilized to reveal their associations.ResultsA total of 24 eligible studies were ultimately enrolled. Our results indicated that SLE was associated with increased risk of overall cancers, cancer risk in both genders, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, leukemia, multiple myeloma, cervix, vagina/vulva, renal, bladder, esophagus, gastric, hepatobiliary, lung, oropharynx, larynx, non-melanoma skin, and thyroid cancers. Additionally, SLE could reduce the risk of prostate cancer and cutaneous melanoma; however, it was not significantly associated with breast, uterus, ovarian, pancreatic, colorectal, or brain cancers.ConclusionsOur results shed light SLE being correlated with increased risk for 16 involved cancers and decreased risk for prostate cancer and cutaneous melanoma. This comprehensive meta-analysis provides epidemiological evidence supporting the associations between SLE and cancer risk. This evidence could be utilized to drive public policies and to help guide personalized medicine to better manage SLE and reduce associated cancer morbidity and mortality.
Highlights
Accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent
Inclusion/exclusion criteria Relevant articles enrolled in this meta-analysis met the following criteria: 1) language was restricted to English publications; 2) patients were diagnosed with SLE; 3) focused on the incidence of cancers in SLE patients; and 4) sufficient data provided by means of Standardized incidence rate (SIR) with 95% Confidence interval (CI)
Our results showed that SLE was correlated with increased risk of non-Hodgkin’s lymphoma (Fig. 2a)
Summary
Accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types. Systemic lupus erythematosus (SLE), defined as a complex and chronic inflammatory autoimmune disease, is characterized by the production of autoantibodies, complement activation, and immune complex deposition, which can be directed against almost any organ system in a heterogeneous array of clinical manifestations [1]. SLE predominantly occurs in young and middle-aged. Song et al Arthritis Research & Therapy (2018) 20:270 First author Year Data origin Calendar period.
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