Abstract
As free-living organisms, bacteria are subject to continuous, numerous and occasionally drastic environmental changes to which they respond with various mechanisms which enable them to adapt to the new conditions so as to survive. Here we describe three situations in which the ribosome and its functions represent the sensor or the target of the stress and play a key role in the subsequent cellular response. The three stress conditions which are described are those ensuing upon: a) zinc starvation; b) nutritional deprivation, and c) temperature downshift.
Highlights
The ribosome is a gigantic ribozyme entirely devoted to decoding the genetic message and to the synthesis of proteins
In this article we focus on the role played by ribosomes and the translational machinery in the cellular response to three different types of stress, namely zinc starvation, nutritional deprivation and cold shock
This causes a generalized inhibition of bulk protein synthesis and mRNA degradation by RNaseR, whereas the translation of only a select group of cold-shock transcripts is favored by the RNA-chaperone activity of the Csp proteins (Ermolenko and Makhatadze, 2002; Hofweber et al, 2005; Zhang et al, 2018)
Summary
The ribosome is a gigantic ribozyme entirely devoted to decoding the genetic message and to the synthesis of proteins. In this article we focus on the role played by ribosomes and the translational machinery in the cellular response to three different types of stress, namely zinc starvation, nutritional deprivation and cold shock.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
