Abstract
The Protein Kinase A Anchoring Protein 13 (AKAP13 or a.k.a. Brx) is a guanine nucleotide-exchange factor for Rho-type small GTP-binding (G), and functions as a cytoplasmic integrator or docking platform for multiple signaling cascades including those of the protein kinase A and nuclear hormone receptors, such as estrogen and glucocorticoid receptors. All these signaling cascades are important for bone metabolism, while Rho-type small G proteins are essential for mediating mechanical stress, an important stimulator of bone formation. Thus, we examined involvement of AKAP13 in the regulation of bone development by employing AKAP13 haploinsufficient mice and MC3T3-E1 cells, an established model of osteoblast differentiation.
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