Abstract
Five normotensive adult patients were given large doses of reserpine for prolonged periods of time before corrective cardiac operations. They were anaesthetized with nitrous oxide and oxygen, supplemented by either halothane or pethidine and suxamethonium. No patient showed evidence of a significant alteration in heart rate or blood pressure with induction or during the maintenance of anaesthesia for a period of 4 to 6 hours. These clinical observations, when related to previous experimental findings, suggest that the hypotension and bradycardia, which sometimes complicate anaesthesia in hypertensive patients receiving reserpine, are related to their underlying cardiovascular disease rather than to the effects of reserpine.
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