Abstract
Antagonists of DNA inhibited the growth of Rous sarcoma virus (RSV) and Rous-associated virus (RAV). Actinomycin D and mitomycin D inhibited the growth of both viruses and demonstrated a general involvement of DNA in virus synthesis. A specific requirement for DNA synthesis in virus growth was demonstrated using 5-iododeoxyuridine and cytosine arabinoside. Inhibition of virus growth by 5-iododeoxyuridine was reduced by the presence of thymidine in the medium, and deoxycytidine prevented inhibition by cytosine arabinoside. The requirement for DNA synthesis in the growth of RSV was transitory, which suggests that a viral DNA “primer” is synthesized in infected cells during the growth cycle of RSV.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
