Abstract

The present study explores the effect of pesticide exposure on the reproductive health and liver function of females participating in agricultural related work. Blood samples were obtained from thirty-five (35) females (out of one hundred females of reproductive age) who were willing donors. Fifty (50) females matched for age and socio economic status was recruited as a control group to compare levels of hormones (estradiol, progesterone and follicle stimulating hormone), liver enzymes-alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Results showed that 56% of the females were illiterate with 48% representing agricultural work. Females who helped in farming operations showed a higher incidence of adverse pregnancy outcome such as abortions and stillbirths compared to non-participants. There was a significant elevation in estradiol and progesterone levels among female agricultural workers. While there was an elevation in serum liver enzymes (AST and ALT) there was a significant decrease in FSH level in females engaged in agricultural activities. The study suggests that participation of females in agricultural activities with potential exposure to pesticides endangers their reproductive health and liver functions.

Highlights

  • Indian economy is largely based on agricultural products and the output primarily depends on extensive use of pesticides

  • We conducted a cross-sectional study in female pesticide sprayers of mango plantation in rural Malihabad, Lucknow

  • Females who helped in preparing pesticides represented 67.16%

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Summary

Introduction

Indian economy is largely based on agricultural products and the output primarily depends on extensive use of pesticides. Agricultural practices involve the use of a diverse group of agro-chemicals that is indiscriminately sprayed by the farmers for pest control. Organophosphorus pesticides (OPs) alone or in combination with organochlorines (OCs) are frequently used and sprayed in mango plantation of Malihabad (Lucknow, U.P.) which is a mango belt in north India and remains an important source of poisoning. These agro-chemicals are popularly termed as pesticides and have been broadly classified in to organophosphorus, organochlorines, carbamates and pyrethroids [1]. In mango field the common pesticide sprayed includes Dichlorovas 76% EC, Monocrotophos 36% EC, Dimethoate 30% EC, Phosphamidon 85% SL Endosulfan 35% EC, Carbaryl, 25% EC, Monocrotophos 36% SL, Methomyl [1]

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