Abstract
Although many mathematical methods were used to analyze the neural activity under sinusoidal stimulation within linear response range in vestibular system, the reliabilities of these methods are still not reported, especially in nonlinear response range. Here we chose nonlinear least-squares algorithm (NLSA) with sinusoidal model to analyze the neural response of semicircular canal neurons (SCNs) during sinusoidal rotational stimulation (SRS) over a nonlinear response range. Our aim was to acquire a reliable mathematical method for data analysis under SRS in vestibular system. Our data indicated that the reliability of this method in an entire SCNs population was quite satisfactory. However, the reliability was strongly negatively depended on the neural discharge regularity. In addition, stimulation parameters were the vital impact factors influencing the reliability. The frequency had a significant negative effect but the amplitude had a conspicuous positive effect on the reliability. Thus, NLSA with sinusoidal model resulted a reliable mathematical tool for data analysis of neural response activity under SRS in vestibular system and more suitable for those under the stimulation with low frequency but high amplitude, suggesting that this method can be used in nonlinear response range. This method broke out of the restriction of neural activity analysis under nonlinear response range and provided a solid foundation for future study in nonlinear response range in vestibular system.
Highlights
The vestibular sensory system is termed the “sixth sense” and plays a vital role in daily life by contributing to visual stabilization [1,2,3], head and body posture maintenance [4,5,6], cognition [7,8,9], spatial orientation construction [10] and navigation [11]
The goal of the present study was to evaluate how reliable the neural response activity can be when described by nonlinear least-squares algorithm (NLSA) with sinusoidal model
We reported for the first time the reliability of NLSA with sinusoidal model on the description of neural response activity during sinusoidal rotational stimulation (SRS) in the vestibular system
Summary
The vestibular sensory system is termed the “sixth sense” and plays a vital role in daily life by contributing to visual stabilization [1,2,3], head and body posture maintenance [4,5,6], cognition [7,8,9], spatial orientation construction [10] and navigation [11]. Nonlinear least-squares algorithm and neural response analysis
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