Abstract
The purpose of this review is to familiarize with the possibilities of using NO-containing gas streams in traumatology and restorative medicine. It reflects the main mechanisms of action of nitric oxide, methods of exogenous delivery of NO and the clinical experience of Russian doctors on the use of NO therapy. The theoretical and clinical data presented in the review substantiate the effectiveness of the use of NO gas streams in injuries and their complications such as scarring processes and chronic osteoarthritis. Nitric oxide is a gas molecule with a wide range of biological effects - bactericidal, vasodilating, pro- and antioxidative, pro- and anti-apoptotic and pro-proliferative. It also has the ability to activate neutrophils and macrophages, potentiate collagen synthesis, which significantly accelerates full-fledged regeneration.
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