Abstract
Function and bother are related but distinct aspects of health-related quality of life. The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of health-related quality of life in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1617 men. Linear regression on the patients’ function and bother summary scores (0-100) from the University of California, Los Angeles Prostate Cancer Index was performed to predict bias-corrected health utilities. Urinary and sexual bother were associated with each health utility, and their coefficients were 3.7 and 20.8 times greater, respectively, than those of the corresponding function. To our knowledge, our study provides the first quantitative and direct comparison of the impacts of function vs bother on health utility.
Highlights
Standardized patient-reported Health-related quality of life (HRQoL) questionnaires, such as the University of California, Los Angeles Prostate Cancer Index (UCLA-PCI), measure function and bother separately for each HRQoL domain
The HRQoL score is needed to calculate a health utility based on prederived weights or formulae [10,11]
Our group determined robust utilities for various outcomes among men participating in the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) [13]
Summary
Chang Wook Jeong , MD, PhD,1,2,* Annika Herlemann, MD, Janet E Cowan, MA, Jeanette M Broering, RN, MPH, PhD, Renske M T ten Ham, PharmD, Leslie S Wilson, PhD, Peter R Carroll, MD, MPH, Matthew R Cooperberg, MD, MPH1,6
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
