Abstract
SUMMARY.— The epidermal barrier unit is composed of cells of the keratinocytic, transitional, and horny layers. The epidermis often contains other dendritic, leukocytic, and neural cells in the intercellular spaces. The epidermal intercellular canals and epidermal phagocytosis are 2 routes of transepidermal and transcorneal passage of materials. Individual, regional, age, and species differences in epidermis may account for variations in cutaneous permeability. Mitotic rate may be the most significant factor in barrier production.
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