The relationship between vitamin D status and markers of diabetes risk in individuals at risk for developing diabetes: preliminary data from the Evidence trial (1041.10)

Abstract

Data from epidemiological studies show an inverse association between low levels of serum 25‐hydroxyvitamin D3 (25(OH)D3) and markers of diabetes risk including high blood glucose levels. The EVIDENCE trial is a randomized, double‐blind clinical trial which aims to examine the effect of vitamin D3 fortified cheese versus placebo on fasting and serum glucose 2h after consuming 75g of glucose (OGTT), insulin, glycated haemoglobin (HbA1c) and markers of inflammation in subjects with low serum 25(OH)D3 (蠄65nmol/ L) and who are at an increased risk for developing type 2 diabetes (T2D). Twenty‐one subjects (11M, 10F) with a mean age of 52 ± 12y enrolled in the EVIDENCE trial visited the laboratory after a 12hr overnight fast. Fasting blood samples were drawn from subjects and assayed for 25(OH)D3, glucose, HbA1c, triglycerides, total, LDL and HDL cholesterol. In this sample of participants enrolled in the EVIDENCE trial we observed a significant inverse association between 25(OH)D3 and triglycerides (r= ‐0.5413, p= 0.011) and waist circumference (r= ‐0.4427, p= 0.045). We also observed an moderate inverse association between serum 25(OH)D3 and HbA1c (r= ‐0.270), however it was not statistically significant. No significant associations were observed between 25(OH)D3 and glucose, total, LDL and HDL cholesterol which may be due to the small sample size. These preliminary data suggests that vitamin D status is inversely related to factors which increase an individual’s risk for developing diabetes.The results from the EVIDENCE trial will assist us in obtaining a better understanding of the potential role of vitamin D in modulating some of the risk factors associated with T2D.Grant Funding Source: Supported by Dairy Farmers of Canada