Abstract
The relationship between the insertion/deletion gene polymorphism of ACE and atrial fibrillation in Chinese population: a meta-analysis
Highlights
In this study, we aimed to explore the relationship between the I/D gene polymorphism of angiotensin-converting enzyme (ACE) and the risk of Atrial fibrillation (AF) in Chinese population
We would select papers when they satisfied those criteria: (1) studies with case-control or cohort; (2) the studies which were to explore the relationship between gene polymorphism of I/D in ACE and the risk of AF; (3) studies with genotype or allele frequencies in patients and control person; (4) studies reported in Chinese population; (5) studies with complete data
A total of 2029 patients with AF and 3371 control person were included. They were used to evaluate the relationship between gene polymorphism of ACE-I/D and AF risk in Chinese
Summary
We aimed to explore the relationship between the I/D gene polymorphism of ACE and the risk of AF in Chinese population. Results: Our results showed that I/D gene polymorphism of ACE increased the risk of AF. The stratified geographical analysis indicated the risk of AF increased significantly in North China. Conclusions: All in all, our results indicated the marked relationship between I/D gene polymorphism of ACE and the increased risk of AF in Chinese population. Common factors include genetic factors, hypertension and heart disease, such as coronary heart disease (Fatkin et al, 2007). To decrease the interfere factors of genetic differences, we conducted a meta-analysis to explore the relationship between the polymorphism of ACE-I/D and the risk of AF in Chinese
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