Abstract
BackgroundDiabetic retinopathy (DR) is one of the most common diseases causing blindness in the world, and most patients are already in advanced stage. Recent years, many studies reported mean platelet volume (MPV) may be associated with development of DR, but there was no consistent conclusion reached.MethodsLiterature was retrieved by formally searching PubMed, Embase, Cochrane library and Scopus and by hand searching of reference lists of related articles. Finally, a total of 14 literatures included, and Review manager 5.3 and STATA 14.0 statistical software were utilized for processing.ResultsMeta-analysis showed that MPV values in DR were significantly higher than health controls [SMD (95% CI) = 0.92 (0.60–1.24)] and type 2 diabetes mellitus without diabetic retinopathy (T2DM without DR) [SMD (95% CI) = 0.36 (0.19–0.53)]. Subgroup analysis indicated that MPV level in proliferative diabetic retinopathy (PDR) patients was higher than T2DM without DR patients [SMD (95% CI) = 0.48 (0.28, 0.68)], but this difference didn’t appear in non-proliferative diabetic retinopathy (NPDR).ConclusionsThe study demonstrated that increased MPV level was significant associated with the development of DR, and it might reflect the severity of DR, which could be provided to monitor development and progression of DR clinically.
Highlights
Diabetic retinopathy (DR) is one of the most common diseases causing blindness in the world, and most patients are already in advanced stage
This study aims to assess and quantify differences in mean platelet volume (MPV) comparing subjects with DR, type 2 diabetes mellitus without diabetic retinopathy (T2DM without DR) and control group, for exploring the relationship between MPV and DR
Selection criteria The inclusion criteria were as follows: (1) published literature related to the association of MPV level with DR; (2) independent case–control studies or cross-section studies using either a hospital-based or a population-based design; (3) the original studies must provide the number of each group and the mean and standard of MPV
Summary
Diabetic retinopathy (DR) is one of the most common diseases causing blindness in the world, and most patients are already in advanced stage. Type 2 diabetes mellitus is a common metabolic disease with all kinds of microvascular diseases occurring. Diabetic retinopathy (DR), a kind of microvascular lesions occurring in fundus, accounts for 40 percent of diabetics over 40 years of age [1], and is the main cause of impaired vision and even blindness in diabetics [2]. The pathogenesis of diabetic retinopathy is not clear, relevant studies have shown that it may be associated with local microvascular injury and microcirculation disorders, and improving blood circulation of the retina effectively before or early in the emergence of DR may prevent it.
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