Abstract
Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology. Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand (FasL) genes and the risk of preeclampsia. However, they achieved inconsistent results. Therefore, we conducted a meta-analysis by systematically searching the Cochrane Library, PubMed and Embase databases and assessed this association by calculating pooled odds ratios with 95% confidence interval to reach a more trustworthy conclusion. Subgroup analyses by genotype methods and source of controls (SOC) were also conducted. Seven citations containing nine studies were included for four SNPs (Fas -670 A/G, FasL 124A/G, FasL -844C/T, Fas -1377 G/A) in this meta-analysis. Our data suggested the G allele and genotype GG of the Fas -670 A/G polymorphism, GG genotype of the FasL 124A/G polymorphism, and TT genotype of the FasL -844C/T polymorphism increased the risk of preeclampsia. Stratification analyses by genotype methods and SOC also indicated that Fas -670 A/G polymorphism was related to increased risk for preeclampsia. In conclusion, Fas and FasL gene polymorphisms play important roles in the development of preeclampsia. Further well-designed studies in other races are needed to confirm the findings of this meta-analysis.
Highlights
Received: 05 November 2018Revised: 15 January 2019Accepted: 30 January 2019Accepted Manuscript Online: Version of Record published: Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology [1].Preeclampsia is marked by elevatory maternal blood pressure and proteinuria after 20 weeks of pregnancy [2]
Sixteen citations were selected for further full-text review
Further replication studies are required to confirm the associations. In this meta-analysis, our data showed that the Fas -670 A/G polymorphism, Fas Ligand (FasL) 124A/G polymorphism, and FasL
Summary
Accepted Manuscript Online: Version of Record published: Preeclampsia is an idiopathic multisystem disorder with partial genetic and immunological etiology [1]. Preeclampsia is marked by elevatory maternal blood pressure and proteinuria after 20 weeks of pregnancy [2]. The physiopathology remains poorly understood, the involvement of metabolic, immune, angiogenic, and genetic factors are suggested [3,4,5,6]. Several studies [7,8] demonstrated an increased apoptosis level of placental villous trophoblasts in pregnancies complicated by preeclampsia. The Fas Ligand (FasL)–FAS (CD95) system is an essential pathway for the initiation of apoptosis in various cells and tissues [9,10,11]. Fas and FasL genes, located on chromosomes 10q24.1 and
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