THE RELATION OF SINUSITIS TO NEPHROSIS IN CHILDREN: A STUDY BASED ON INVESTIGATIONS AT THE CHILDREN'S HOSPITAL, LOS ANGELES, 1929

Abstract

The pathologic process in true nephrosis is confined to the tubular portion of the kidney. All grades of tubular changes may be noted. The cells become granular in an early stage, and finally shed off and regenerate in a lower type as the disease progresses. A pure tubular nephrosis is rare, however, as secondary glomerular changes and interstitial changes are frequent. The glomerular capsule becomes thickened; later the glomerular tuft becomes adherent to the capsule, and finally there is entire obliteration of the tuft. Interstitial changes with round cell infiltration also take place. The condition is then one of chronic parenchymatous nephritis or a mixed nephritis and nephrosis. A somewhat similar picture is sometimes obtained when, following acute glomerular nephritis, as sometimes results from scarlet fever, a secondary degeneration of the tubules occurs. The etiologic agent in this case may be bacterial, in which case the changes in the kidney