Abstract
BackgroundDiabetic kidney disease (DKD) is the leading cause of renal failure. Diabetic patients with microalbuminuria typically progress to proteinuria and overt diabetic nephropathy. Nesfatin-1 is an anoretic polypeptide with potent metabolic regulatory effects and its circulating levels are shown to be elevated in type 2 diabetes mellitus (T2 DM).Nesfatin-1 may be involved in the pathogenesis of DKD through inflammatory mechanisms.The aim of the work was to study the relation between plasma nesfatin-1 levels and different grades of DKD in patients with T2 DM.Patients and methodsThis study was conducted on 120 patients with T2 DM and 20 controls selected from the inpatient department and outpatient clinics of the Internal Medicine Department in Menoufia University Hospital. The selected individuals were grouped into four groups: group1 included 20 healthy individuals, group 2 included 40 patients with T2DM with normoalbuminuria, group 3 included 40 patients with T2 DM with microalbuminuria, and group 4 included 40 patients with T2 DM with macroalbuminuria.Members of the study were subjected to thorough history with special emphasis on age, sex, and duration of the DM. Investigations included fasting blood glucose, glycosylated hemoglobin, complete urine analysis, serum creatinine, urine albumin–creatinine ratio, estimated glomerular filtration rate, and plasma nesfatin-1.ResultsPlasma nesfatin-1 was significantly higher in group 4 compared with other groups, in group 3 compared with groups 1 and 2, and in group 2 compared with group 1. There was a positive significant correlation between plasma nesfatin-1 and serum creatinine, urine albumin–creatinine ratio, and glycosylated hemoglobin and negative significant correlation between plasma nesfatin-1 and estimated glomerular filtration rate in the studied diabetic patients. There was no correlation between plasma nesfatin-1 and BMI and duration of diabetes in the diabetic patients.ConclusionFrom this study, we can conclude that plasma nesfatin-1 is significantly higher in patients with DKD, and there is a positive correlation between plasma nefatin-1 level and the grades of DKD. So, plasma nesfatin-1 may be considered for prediction of developing DKD in a previously unaffected patients with DM.
Highlights
Nesfatin-1 is an 82 amino-acid length polypeptide derived from calcium and DNA-binding protein NUCB2 [1].The nesfatin-1 is promimently expressed in several regions of the hypothalamus nuclei
Urine albumin–creatinine ratio (UACR) was significantly higher in group 4 compared with other groups and in group 3 compared with groups 2 and 1
The estimated glomerular filtration rate was significantly lower in group 4 compared with other groups and in group 3 compared with groups 1 and 2 (Table 1)
Summary
Nesfatin-1 is an 82 amino-acid length polypeptide derived from calcium and DNA-binding protein NUCB2 [1].The nesfatin-1 is promimently expressed in several regions of the hypothalamus nuclei. The aim of the work was to study the relation between plasma nesfatin-1 levels and different grades of DKD in patients with T2 DM. Investigations included fasting blood glucose, glycosylated hemoglobin, complete urine analysis, serum creatinine, urine albumin–creatinine ratio, estimated glomerular filtration rate, and plasma nesfatin-1. Results Plasma nesfatin-1 was significantly higher in group 4 compared with other groups, in group 3 compared with groups 1 and 2, and in group 2 compared with group 1. There was a positive significant correlation between plasma nesfatin-1 and serum creatinine, urine albumin–creatinine ratio, and glycosylated hemoglobin and negative significant correlation between plasma nesfatin-1 and estimated glomerular filtration rate in the studied diabetic patients. Conclusion From this study, we can conclude that plasma nesfatin-1 is significantly higher in patients with DKD, and there is a positive correlation between plasma nefatin-1 level and the grades of DKD. Plasma nesfatin-1 may be considered for prediction of developing DKD in a previously unaffected patients with DM
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
