Abstract
AbstractBackground: Vitamin D had an important influence on the innate and adaptive immune system. 25-hydroxyvitamin D (25(OH)D) serum level is known to be the best predictor of vitamin D level. Objective is to determine the relationship between neonatal 25(OH)D level in early-onset sepsis (EOS) and its severity in term infants. Methods: This case-control study was performed on 50 septic neonates admitted to Fayoum University Hospitals' Neonatal Intensive Care Unit as a case group, and 50 healthy neonates as a control group. Each subject was subjected to a detailed history and meticulous general & systemic examinations. Laboratory assessment in form of complete blood count with differential counts, C-reactive protein (CRP), blood culture, and serum 25(OH)D level in infants and within 72 hours of life.Results: 25(OH)D levels in cases (4.91 ng/ml) were significantly lowered than those in controls (13.0 ng/ml) (p
Highlights
Neonatal sepsis is characterized as a systemic inflammatory response occurring as a result of a suspected or confirmed infection in the first four weeks of life [1]
The case group composed of 50 term neonates who admitted to Neonatal Intensive Care Units (NICUs) within the first three postnatal days with laboratory findings and clinical features suggesting early-onset sepsis (EOS) according to Griffin Neonatal Sepsis Score [9]
General characteristics of the studied groups We classified the patients into 2 groups: Case group including 50 neonates [26 (52.0%) females, 24 (48.0%) males] with evidence of sepsis, and control group including 50 healthy stable full-term neonates
Summary
Neonatal sepsis is characterized as a systemic inflammatory response occurring as a result of a suspected or confirmed infection in the first four weeks of life [1]. Objectives: To determine the relationship between neonatal 25(OH)D level in early-onset sepsis (EOS) and its severity in term infants. Laboratory assessment in form of complete blood count with differential counts, C-reactive protein (CRP), blood culture, and serum 25(OH)D level in infants was done within 72 hours of life. The number and percentage of mothers with no history of vitamin D supplements throughout pregnancy was statistically significantly higher in cases (n=48;96.0%) than in controls (n=42;84.0%; p=0.046). Vitamin D mean level was lowered in the case with positive blood culture compared to negative blood culture (4.8ng/ml vs 5.02 ng/ml) respectively with no statistical significance Conclusions: Earlyonset sepsis in term infant occurs more frequently in the presence of Vit-D deficiency
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