Abstract
AORTOGRAPHY is a remarkably innocuous procedure considering that at least 30 gm of an organic salt containing 50% to 70% iodine is introduced into the circulation within a period of two to three seconds. However, complications have been reported and the kidney appears to be the most vulnerable organ.<sup>1</sup>Extensive investigations have been carried out to determine the mechanisms responsible for the toxicity of radiopaque materials. Previous work<sup>2-4</sup>from this laboratory has emphasized the role of red cell crenation and aggregation with a resulting increase in blood viscosity. These changes may lead to thromboembolism and ischemia. The purpose of the present study was to determine whether renal damage arising from angiographic media represents a direct toxic effect on the parenchyma<sup>5</sup>or is, as has been demonstrated for concentrated saline,<sup>6</sup>a secondary phenomenon related to changes induced in the renal circulation. <h3>Methods</h3> The experimental preparation used in
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